NYMC Faculty Publications
Methadone-induced Hyperhidrosis Treated With Oxybutynin
DOI
10.1097/ADM.0000000000000300
Journal Title
Journal of Addiction Medicine
First Page
237
Last Page
238
Document Type
Article
Publication Date
May 2017
Department
Psychiatry and Behavioral Sciences
Keywords
case reports, opioid analgesics, mandelic acids, muscarinic antagonists, oxybutynin, methadone, hyperhidrosis chemically induced, adverse effects, therapeutic use, opiate substitution treatment adverse effects
Disciplines
Medicine and Health Sciences
Abstract
OBJECTIVES: This case report aims to help healthcare providers and methadone clinic patients to recognize one of the less recognized adverse effects of methadone, hyperhidrosis, and to suggest oxybutynin as a possible solution. METHODS: A 35-year-old man on methadone maintenance therapy presented with excessive sweating, which began promptly after methadone was introduced. Urine toxicology was conducted every 2 weeks to rule out other illicit substances that may have contributed to the sweating. RESULTS: Oxybutynin (5 mg PO QID) resulted in cessation of the methadone-induced hyperhidrosis within 2 days of starting the medication. CONCLUSIONS: Methadone-induced excessive sweating is an adverse effect of the medication that reportedly affects up to 45% of those prescribed methadone, and oxybutynin is a potent treatment for methadone-induced excessive sweating.
Recommended Citation
Hong, J., Lee, J., Totouom-Tangho, H., Dunn, N., & Swift, R. (2017). Methadone-induced Hyperhidrosis Treated With Oxybutynin. Journal of Addiction Medicine, 11 (3), 237-238. https://doi.org/10.1097/ADM.0000000000000300
