NYMC Faculty Publications

Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis

Author Type(s)

Resident/Fellow, Faculty

DOI

10.14309/crj.0000000000001467

Journal Title

ACG Case Reports Journal

First Page

e01467

Document Type

Article

Publication Date

8-1-2024

Department

Medicine

Second Department

Pathology, Microbiology and Immunology

Abstract

Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.

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