Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis

Authors

Wei Tang, Department of Internal Medicine, New York Medical College, Valhalla, NY.
Zilan Lin, Department of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Valhalla, NY.
Pritika Sharma, Department of Internal Medicine, New York Medical College, Valhalla, NY.
Gabriel Heering, Department of Internal Medicine, New York Medical College, Valhalla, NY.
Brad Dworkin, Department of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Valhalla, NY.
Amir Steinberg, Department of Hematology and Oncology, New York Medical College, Valhalla, NY.
Fouzia Shakil, Department of Pathology, New York Medical College, Valhalla, NY.
Beth Schorr-Lesnick, Department of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Valhalla, NY.

Author Type(s)

Resident/Fellow, Faculty

DOI

10.14309/crj.0000000000001467

Journal Title

ACG Case Reports Journal

First Page

e01467

Document Type

Article

Publication Date

8-1-2024

Department

Medicine

Second Department

Pathology, Microbiology and Immunology

Keywords

Campylobacter jejuni, Giardia lamblia, Helicobacter pylori, extranodal marginal zone lymphoma, heavy chain disease, mucosa associated lymphoid tissue lymphoma

Abstract

Alpha heavy chain disease (αHCD) is a rare variant of the mucosa-associated lymphoid tissue lymphoma characterized by expression of a monotypic truncated immunoglobulin α heavy chain. αHCD frequently involves the gastrointestinal (GI) tract, and its pathogenesis has been linked to clonal B-cell expansion from chronic immune stimulation by infectious agents. We report a rare case of GI αHCD with 5 concomitant pathogens identified on a GI multiplex real-time polymerase chain reaction panel, featured by persistent Campylobacter jejuni colonization and refractory giardiasis.

Recommended Citation

Tang, W., Lin, Z., Sharma, P., Heering, G., Dworkin, B., Steinberg, A., Shakil, F., & Schorr-Lesnick, B. (2024). Gastrointestinal Alpha Heavy Chain Disease With Persistent Campylobacter Jejuni Colonization and Refractory Giardiasis. ACG Case Reports Journal, 11 (8), e01467. https://doi.org/10.14309/crj.0000000000001467