NYMC Faculty Publications
Improving Glaucoma Detection Using Spatially Correspondent Clusters of Damage and by Combining Standard Automated Perimetry and Optical Coherence Tomography
Author Type(s)
Faculty
DOI
10.1167/iovs.13-12351
Journal Title
Investigative Ophthalmology & Visual Science
First Page
612
Last Page
624
Document Type
Article
Publication Date
1-29-2014
Department
Ophthalmology
Keywords
Algorithms, Female, Glaucoma, Humans, Male, Middle Aged, Optic Disk, ROC Curve, Reproducibility of Results, Retinal Ganglion Cells, Tomography, Optical Coherence, Visual Field Tests, Visual Fields
Disciplines
Medicine and Health Sciences
Abstract
PURPOSE: To improve the detection of glaucoma, techniques for assessing local patterns of damage and for combining structure and function were developed.
METHODS: Standard automated perimetry (SAP) and frequency-domain optical coherence tomography (fdOCT) data, consisting of macular retinal ganglion cell plus inner plexiform layer (mRGCPL) as well as macular and optic disc retinal nerve fiber layer (mRNFL and dRNFL) thicknesses, were collected from 52 eyes of 52 healthy controls and 156 eyes of 96 glaucoma suspects and patients. In addition to generating simple global metrics, SAP and fdOCT data were searched for contiguous clusters of abnormal points and converted to a continuous metric (pcc). The pcc metric, along with simpler methods, was used to combine the information from the SAP and fdOCT. The performance of different methods was assessed using the area under receiver operator characteristic curves (AROC scores).
RESULTS: The pcc metric performed better than simple global measures for both the fdOCT and SAP. The best combined structure-function metric (mRGCPL&SAP pcc, AROC = 0.868 ± 0.032) was better (statistically significant) than the best metrics for independent measures of structure and function. When SAP was used as part of the inclusion and exclusion criteria, AROC scores increased for all metrics, including the best combined structure-function metric (AROC = 0.975 ± 0.014).
CONCLUSIONS: A combined structure-function metric improved the detection of glaucomatous eyes. Overall, the primary sources of value-added for glaucoma detection stem from the continuous cluster search (the pcc), the mRGCPL data, and the combination of structure and function.
Recommended Citation
Raza, A. S., Zhang, X., De Moraes, C. G., Reisman, C. A., Liebmann, J. M., Ritch, R., & Hood, D. C. (2014). Improving Glaucoma Detection Using Spatially Correspondent Clusters of Damage and by Combining Standard Automated Perimetry and Optical Coherence Tomography. Investigative Ophthalmology & Visual Science, 55 (1), 612-624. https://doi.org/10.1167/iovs.13-12351
