NYMC Faculty Publications
Rituximab With Chemotherapy in Children and Adolescents With Central Nervous System and/or Bone Marrow-Positive Burkitt Lymphoma/Leukaemia: A Children's Oncology Group Report
Author Type(s)
Faculty
DOI
10.1111/bjh.13040
Journal Title
British Journal of Haematology
First Page
394
Last Page
401
Document Type
Article
Publication Date
11-1-2014
Department
Medicine
Keywords
Adolescent, Antibodies, Monoclonal, Murine-Derived, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow, Burkitt Lymphoma, Central Nervous System Neoplasms, Child, Consolidation Chemotherapy, Cyclophosphamide, Cytarabine, Disease-Free Survival, Doxorubicin, Drug Administration Schedule, Etoposide, Female, Genes, myc, Humans, Immunotherapy, Infusions, Intravenous, Kaplan-Meier Estimate, Lymphoma, B-Cell, Maintenance Chemotherapy, Male, Methotrexate, Prednisone, Remission Induction, Rituximab, Typhlitis, Vincristine
Disciplines
Medicine and Health Sciences
Abstract
Children and adolescents with Burkitt Lymphoma (BL) and combined central nervous system (CNS) and bone marrow involvement still have a poor prognosis with chemotherapy alone. We therefore investigated in children and adolescents with bone marrow (≥25% blasts) and/or CNS-positive Burkitt lymphoma the chemoimmunotherapy combination of rituximab (375 mg/m(2) ) and the standard chemotherapy arm of our previously reported French-American-British (FAB) Lymphome Malins de Burkitt (LMB) 96 trial. Central pathological and cytogenetic characterization was also performed. There were 40 evaluable patients with Burkitt histology (25 with leukaemia and 15 with CNS disease ± leukaemia). The chemoimmunotherapy regimen was well tolerated. The incidence of grade III/IV mucositis during induction cycles with combined chemotherapy and rituximab was 31% and 26%, respectively. The 3-year event-free survival (EFS)/overall survival (OS) was 90% (95% confidence interval [CI], 76-96%) in the entire cohort and 93% (95% CI, 61-99%) in patients with CNS disease. Based on the results of this trial, an international randomized study of FAB/LMB 96 chemotherapy ± rituximab for high-risk patients is currently under investigation.
Recommended Citation
Goldman, S., Smith, L., Galardy, P., Perkins, S. L., Frazer, J., Sanger, W., Anderson, J. R., Gross, T. G., Weinstein, H., Harrison, L., Shiramizu, B., Barth, M., & Cairo, M. (2014). Rituximab With Chemotherapy in Children and Adolescents With Central Nervous System and/or Bone Marrow-Positive Burkitt Lymphoma/Leukaemia: A Children's Oncology Group Report. British Journal of Haematology, 167 (3), 394-401. https://doi.org/10.1111/bjh.13040
