Gender-Based Comparison of Cardiovascular Outcomes and Readmission in Patients With Patent Foramen Ovale Closure Procedure: A Nationwide Readmissions Database Analysis
Author Type(s)
Resident/Fellow
Document Type
Abstract
Publication Date
2022
DOI
10.1016/j.jacc.2022.08.654
Journal Title
Journal of the American College of Cardiology
Department
Medicine
Abstract
Background: Patent foramen ovale (PFO) is a common abnormality affecting 20% to 34% of the adult population, and it is a well-known risk factor for ischemic stroke. However, the gender-based differences in cardiovascular outcomes and readmission for PFO closure are not well documented. Methods: Using the Nationwide Readmissions Database (2016-2019), PFO closure procedures were identified and divided into male and female groups. The 2 groups were compared by using STATA version 17. A weighted descriptive analysis was performed to generate national estimates. Results: A total of 7,835 patients with PFO closure procedure were identified, of whom 3,196 (40.7%) were female and 2,757 (35.2%) were male. A statistically significantly higher prevalence of hypothyroidism (13.55%) was noted in the female patients compared with male patients (P < 0.05). Meanwhile, a statistically significantly higher prevalence of hyperlipidemia (44.5%), hypertension (24.0%), smoking (24.3%), prior percutaneous coronary intervention (PCI) (4.9%), prior coronary artery bypass graft (CABG) (6.5%), and obstructive sleep apnea (OSA) (12.6%) was noted in the male cohort (P < 0.05). There was no statistically significant difference in readmission rates at 30, 90, and 180 days among male and female cohorts. We observed significantly higher hospital deaths (3.0%), acute kidney injury (36.2%), stroke (20.1%), myocardial infarction (MI) (2.3%), need for mechanical circulatory support (1.4%), and major adverse cardiac and cerebrovascular event (MACCE) in male cohorts compared with female cohorts (P < 0.05). No significant differences were noticed in the outcome of heart failure between the 2 groups. [Formula presented] Conclusion: PFO closure is associated with significantly higher adverse events in men compared vs women with similar readmission rates. Categories: STRUCTURAL: Congenital and Other Structural Heart Disease
Recommended Citation
Fakhra, S., Sattar, Y., Patel, N., Titus, A., Bdiwi, M., Al-Taweel, O., & Alraies, C. (2022). Gender-Based Comparison of Cardiovascular Outcomes and Readmission in Patients With Patent Foramen Ovale Closure Procedure: A Nationwide Readmissions Database Analysis. Journal of the American College of Cardiology, 80 (12), B228. https://doi.org/10.1016/j.jacc.2022.08.654
