NYMC Faculty Publications

Contemporary Management of Ischemic Cardiomyopathy: The Synergy of Medical, Revascularization, and Device Therapies

DOI

10.1016/j.pcad.2025.04.001

Journal Title

Progress in Cardiovascular Diseases

First Page

16

Last Page

24

Document Type

Article

Publication Date

9-1-2025

Department

Medicine

Keywords

Heart failure, Ischemic cardiomyopathy, Medical therapy, Revascularization, Synergy

Disciplines

Medicine and Health Sciences

Abstract

Ischemic heart disease (IHD) is the leading global cause of death, affecting millions and leading to significant morbidity and mortality. Ischemic cardiomyopathy (ICM), a manifestation of IHD, results in severe left ventricular dysfunction due to coronary artery disease and poses a significant challenge due to the complex pathophysiology, variable clinical presentation, and overall poor prognosis. Recent advances in medical therapy, device interventions, and revascularization techniques offer newfound hope in improving ICM patient outcomes. This article reviews the state-of-the-art management approaches for ICM, emphasizing the importance of personalized treatment plans that integrate the various contemporary therapies to address the multiple mechanisms of disease development and progression. A meticulously tailored treatment approach for each individual patient offers the hope of prolonged survival through the synergy of therapies designed to address the different and complex mechanisms that contribute to their disease process.

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