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Abstract

Neddylation plays a critical role in proteosomal degradation and the progression of the cell cycle. Inter- fering with the process of neddylation and deneddylation could provide points of therapy by promoting cell death or cell cycle arrest in cells that are undergoing rapid proliferation, such as in tumors. The cy- cle of neddylation and deneddylation is essential for cellular processes, and if it is inhibited or amplified in some way, this may disturb the proliferation of tumor and with further research, it may be used as a target for cancer therapy.

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