In a January 2010 study conducted at the University of Pennsylvania, investigators determined that for patients who had less than “very severe depression”, antidepressants have no measurable effect on de- pressive symptoms when compared to placebo. This resounding statement was widely circulated by every major national media outlet. If true, it has powerful implications for the millions of Americans who are currently prescribed antidepressants. The commentary at hand highlights several glaring flaws in the design and conclusions of these researchers’ meta-analysis, in an attempt to portray their findings in a less alarming and more realistic light.



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